cb1/2 agonist 2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62180	CB1/2 agonist 2
	CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand with Ki of 3.5 nM and 1.2 nM, respectively. CB1/2 agonist 2 is a full agonist of CB1 and a competitive inverse agonist of CB2. BACE-IN-1 is a com...
T62411	CB1/2 agonist 4
	CB1/2 agonist 4 (compound 24) is a CB1 full agonist (EC50: 15.09 nM) and a CB2 partial agonist (EC50: 1.16 nM). CB1/2 agonist 4 has significant anti-harm-sensing activity and also activates cannabinoid and TRPV1 receptor...
T61736	CB1/2 agonist 3
	CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a competitive agonist for the CB1/CB2 receptors. It exhibits CB1/CB2 agonistic activity by binding to the human CB1 and CB2 receptors, with Ki ...
T72395	CB1 inverse agonist 2
	CB1 Inverse Agonist 2, an orally active compound, serves as an inverse agonist for the Cannabinoid Receptor CB1. It effectively counteracts the hypothermia and anorexia induced by CP55940 in mouse models.
T62468	CB1/2 agonist 1
	CB1/2 agonist 1 is a potent CB1/2 agonist that crosses the blood-brain barrier, acting on CB1R (EC50: 56.15 nM) and CB2R (EC50: 11.63 nM). CB1/2 agonist 1 reduces glutamate release and LPS-induced microglia activation, a...
T6527	GW842166X		Cannabinoid Receptor
	GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.		Cannabinoid Receptor
T6417	BML-190	Indomethacin morpholinylamide,IMMA,BML 190	Cannabinoid Receptor
	BML-190 (Indomethacin morpholinylamide) is a specific CB2 receptor inverse agonist (Ki: 435 nM), with 50-fold selectivity over CB1 receptor.		Cannabinoid Receptor
T7316	LY2828360		Cannabinoid Receptor
	LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, respectively).		Cannabinoid Receptor
TN1465	Cannabigerol		NOS , 5-HT Receptor , ROS
	Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur...		NOS , 5-HT Receptor , ROS
T24771	SCH-336	SCH336,SCH 336	Cannabinoid Receptor
	SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 red...		Cannabinoid Receptor
T41231	GP 1a		Cannabinoid Receptor , PERK , Arrestin
	GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and incr...		Cannabinoid Receptor , PERK , Arrestin
TP1900L1	Hemopressin (human, mouse) acetate	Hemopressin (human, mouse) acetate(1314035-51-2 free base)	Cannabinoid Receptor
	Hemopressin (human, mouse) acetate is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabino...		Cannabinoid Receptor
T8571	ML-184	CID2440433	Cannabinoid Receptor
	ML-184 (CID2440433) is a potent synthetic agonist of GPR55 with EC50 of 0.26 μM.		Cannabinoid Receptor
T62584	CBR Agonist-2
	CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) (EC50: 960 nM, Ki: 970 nM). CBR Agonist-2 is a promising tool for the study of endogenous cannabinoid system-related diseases involving hCB1R.
T17027	Tedalinab	GRC-10693	Cannabinoid Receptor
	Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab has >4700-fold functional selectivity for CB2 over CB1.		Cannabinoid Receptor
T38199	(±)-WIN 55,212 (mesylate)
	(±)-WIN 55,212-2 is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki value of 62.3 and 3.3 nM for human recombinant central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors, respectively....
T38115	Fluprostenol serinol amide
	2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB1 receptor. 2-AG c...
T75936	RVD-Hpα TFA
	RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca 2+ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA a...
T69740	AMG-315
	AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the ...
T38138	ACEA	2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces ...